Macau (/məˈkaʊ/; 澳門; 澳门; literally: "Bay Gate"), also spelled Macao, officially the Macao Special Administrative Region of the People's Republic of China, is an autonomous territory on the western side of the Pearl River Delta in East Asia. Macau is bordered by the city of Zhuhai in China to the North and the Pearl River Estuary to the East and South. Hong Kong lies about 64 kilometres (40 mi) to its East across the Delta. With an estimated population of around 647,700 living in an area of 30.5 km² (11.8 sq mi), it is the most densely populated region in the world.
Macau was administered by the Portuguese Empire and its inheritor states from the mid-16th century until late 1999, when it constituted the last remaining European colony in Asia. Portuguese traders first settled in Macau in the 1550s. In 1557, Macau was rented to Portugal from Ming China as a trading port. The Portuguese Empire administered the city under Chinese authority and sovereignty until 1887, when Macau, through a mutual agreement between the two countries, became a colony. Sovereignty over Macau was transferred back to China on 20 December 1999. The Joint Declaration on the Question of Macau and Macau Basic Law stipulate that Macau operate with a high degree of autonomy until at least 2049, fifty years after the transfer.
Under the policy of "one country, two systems", the State Council of the People's Republic of China is responsible for military defense and foreign affairs while Macau maintains its own legal system, public security force, monetary system, customs policy, and immigration policy. Macau participates in international organizations and events that do not require members to possess national sovereignty.
Macau is among the world's richest regions, and as of 2015 its GDP per capita by purchasing power parity is higher than that of any country in the world, according to the World Bank. It became the world's largest gambling centre in 2006, with the economy heavily dependent on gambling and tourism, as well as manufacturing. According to The World Factbook, Macau has the fourth highest life expectancy in the world. Moreover, it is one of the regions in Asia with a "very high Human Development Index", ranking 18th in the world as of 2014.